SMX · 10 mg / vial
Semax
$100
In stockHeptapeptide derived from the N-terminal fragment of ACTH (4-10).
- Purity
- ≥ 99.0%
- Dose
- 10 mg / vial
- Form
- Lyophilized
- QC
- HPLC + MS
What it does
Semax is a heptapeptide derived from the ACTH(4-10) fragment but stripped of any hormonal (corticotropic) activity. Developed in Russia and on the WHO essential medicines list there for stroke recovery, it is one of the most well-characterised nootropic peptides for cognition, attention and neuroprotection. Effects are typically felt within minutes of intranasal dosing and persist for several hours.
How it works in the body
It boosts the brain's own 'fertiliser' chemicals (BDNF and NGF) that help nerve cells grow stronger connections — basically helping your brain learn and remember better. It also tops up the feel-good and focus chemicals (dopamine and friends) and protects brain cells when they're under stress.
Researched benefits
- Sharper focus, working memory and verbal fluency
- Faster recall and learning during high-cognitive-load periods
- Neuroprotection — studied in stroke and traumatic brain injury recovery
- Improved mood and motivation via dopaminergic modulation
- Reduced mental fatigue without stimulant-like crash
Typical research protocol
- Reconstitution
- Reconstitute with 2 mL bacteriostatic water → 5 mg/mL (50 mcg per pen unit).
- Dose
- Typical research dose: 250–600 mcg per administration.
- Pen units (U-100)
- 300 mcg = 6 units, 600 mcg = 12 units on a U-100 peptide pen.
- Frequency
- 1–2× per day in the morning and early afternoon, often run in 10–14 day cycles.
Recommended: use a single-use, sterile drawing syringe and needle for reconstitution — available in the accessories section.
For in-vitro research only — not for human or veterinary consumption.
Deep dive · properties
The nerdy details 🔬
- Half-life
- ~few minutes systemic, hours central (intranasal)
- Sequence / class
- Met-Glu-His-Phe-Pro-Gly-Pro (ACTH 4-7 analog)
- Molecular weight
- ≈ 813.9 Da
- Storage & stability
- Store lyophilized vials at –20 °C for long-term storage (up to 24 months). Once reconstituted, refrigerate at 2–8 °C and use within 28 days. Protect from light and freeze/thaw cycles.
Published research
Where the data lives 📚
- Gusev EI, et al. Semax in ischemic stroke ↗
Zh Nevrol Psikhiatr, 2005
- Kaplan AY, et al. Synthetic ACTH analog Semax and cognitive function ↗
Neuroscience & Behavioral Physiology, 1996
Linked purely for research context. Sold for laboratory use only.
Often studied alongside
Pairs well with 💫
Semax
$100 · 10 mg / vial