Retatrutide vs Tirzepatide vs AOD-9604 vs MOTS-c
All three show up in 'metabolic' conversations, but they hit different pathways. One acts on incretin receptors, one on fat cells directly, and one is a signal from your mitochondria.
Retatrutide
$300 · 40 mg / vial
- Best for
- Weight, glucose, hepatic fat (largest effect size)
- Mechanism
- Triple agonist — GLP-1 + GIP + glucagon
- Half-life
- ~6 days
- Dosing
- 2 → 12 mg weekly titration
- Ideal timing
- Once weekly, same day each week (any time)
- Notes
- Largest weight reductions observed in any peptide trial to date.
AOD-9604
$150 · 5 mg / vial
- Best for
- Selective lipolysis studies
- Mechanism
- hGH C-terminal fragment — direct fat-cell signaling
- Half-life
- ~30 min
- Dosing
- 300–600 mcg daily
- Ideal timing
- Morning, fasted (30+ min before food)
- Notes
- Doesn't touch appetite pathways — very different from GLP-1 class.
MOTS-c
$54 · 5 mg / vial
- Best for
- Insulin sensitivity, exercise-mimetic research
- Mechanism
- Mitochondrial-derived peptide — nuclear metabolic signal
- Half-life
- ~1–2 h
- Dosing
- 5–10 mg per week split across days
- Ideal timing
- Morning on training days, pre-exercise
- Notes
- Growing longevity/aging research pipeline.